Chromosomal localization of mitochondrial transcription factor A (TCF6), single-stranded DNA-binding protein (SSBP), and endonuclease G (ENDOG), three human …
V Tiranti, E Rossi, A Ruiz-Carrillo, G Rossi, M Rocchi… - Genomics, 1995 - Elsevier
Genomics, 1995•Elsevier
By using a PCR-based screening of a somatic cell hybrid panel and FISH, we have
assigned the loci of mitochondrial single-stranded DNA-binding protein (SSBP),
mitochondrial transcription factor A (TCF6), and mitochondrial endonuclease G (ENDOG)
genes to human chromosomes 7q34, 10q21, and 9q34. 1, respectively. The products of
these three genes are involved in fundamental aspects of mitochondrial biogenesis, such as
replication and transcription of the mitochondrial genome. The chromosomal localization of …
assigned the loci of mitochondrial single-stranded DNA-binding protein (SSBP),
mitochondrial transcription factor A (TCF6), and mitochondrial endonuclease G (ENDOG)
genes to human chromosomes 7q34, 10q21, and 9q34. 1, respectively. The products of
these three genes are involved in fundamental aspects of mitochondrial biogenesis, such as
replication and transcription of the mitochondrial genome. The chromosomal localization of …
By using a PCR-based screening of a somatic cell hybrid panel and FISH, we have assigned the loci of mitochondrial single-stranded DNA-binding protein (SSBP), mitochondrial transcription factor A (TCF6), and mitochondrial endonuclease G (ENDOG) genes to human chromosomes 7q34, 10q21, and 9q34.1, respectively. The products of these three genes are involved in fundamental aspects of mitochondrial biogenesis, such as replication and transcription of the mitochondrial genome. The chromosomal localization of these genes is important to testing whether the corresponding proteins may play a role in the etiopathogenesis of human disorders associated with qualitative or quantitative abnormalities of mitochondrial DNA.
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