Store-operated CRAC channel inhibitors: opportunities and challenges
C Tian, L Du, Y Zhou, M Li - Future medicinal chemistry, 2016 - Future Science
C Tian, L Du, Y Zhou, M Li
Future medicinal chemistry, 2016•Future ScienceAberrant Ca2+ release-activated Ca2+ (CRAC) channel activity has been implicated in a
number of human disorders, including immunodeficiency, autoimmunity, occlusive vascular
diseases and cancer, thus placing CRAC channels among the important targets for the
treatment of these disorders. We briefly summarize herein the molecular basis and activation
mechanism of CRAC channel and focus on discussing several pharmacological inhibitors of
CRAC channels with respect to their biological activity, mechanisms of action and selectivity …
number of human disorders, including immunodeficiency, autoimmunity, occlusive vascular
diseases and cancer, thus placing CRAC channels among the important targets for the
treatment of these disorders. We briefly summarize herein the molecular basis and activation
mechanism of CRAC channel and focus on discussing several pharmacological inhibitors of
CRAC channels with respect to their biological activity, mechanisms of action and selectivity …
Aberrant Ca2+ release-activated Ca2+ (CRAC) channel activity has been implicated in a number of human disorders, including immunodeficiency, autoimmunity, occlusive vascular diseases and cancer, thus placing CRAC channels among the important targets for the treatment of these disorders. We briefly summarize herein the molecular basis and activation mechanism of CRAC channel and focus on discussing several pharmacological inhibitors of CRAC channels with respect to their biological activity, mechanisms of action and selectivity over other types of Ca2+ channel in different types of cells.
Future Science