Calcium signalling in lymphocyte activation and disease

S Feske - Nature Reviews Immunology, 2007 - nature.com
Nature Reviews Immunology, 2007nature.com
Calcium signals in cells of the immune system participate in the regulation of cell
differentiation, gene transcription and effector functions. An increase in intracellular levels of
calcium ions (Ca2+) results from the engagement of immunoreceptors, such as the T-cell
receptor, B-cell receptor and Fc receptors, as well as chemokine and co-stimulatory
receptors. The major pathway that induces an increase in intracellular Ca2+ levels in
lymphocytes is through store-operated calcium entry (SOCE) and calcium-release-activated …
Abstract
Calcium signals in cells of the immune system participate in the regulation of cell differentiation, gene transcription and effector functions. An increase in intracellular levels of calcium ions (Ca2+) results from the engagement of immunoreceptors, such as the T-cell receptor, B-cell receptor and Fc receptors, as well as chemokine and co-stimulatory receptors. The major pathway that induces an increase in intracellular Ca2+ levels in lymphocytes is through store-operated calcium entry (SOCE) and calcium-release-activated calcium (CRAC) channels. This Review focuses on the role of Ca2+ signals in lymphocyte functions, the signalling pathways leading to Ca2+ influx, the function of the recently discovered regulators of Ca2+ influx (STIM and ORAI), and the relationship between Ca2+ signals and diseases of the immune system.
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