[HTML][HTML] Characterization of diabetogenic CD8+ T cells: immune therapy with metabolic blockade
JW Garyu, M Uduman, A Stewart, J Rui, S Deng… - Journal of Biological …, 2016 - ASBMB
Type 1 diabetes mellitus is caused by the killing of insulin-producing β cells by CD8+ T cells.
The disease progression, which is chronic, does not follow a course like responses to
conventional antigens such as viruses, but accelerates as glucose tolerance deteriorates. To
identify the unique features of the autoimmune effectors that may explain this behavior, we
analyzed diabetogenic CD8+ T cells that recognize a peptide from the diabetes antigen
IGRP (NRP-V7-reactive) in prediabetic NOD mice and compared them to others that shared …
The disease progression, which is chronic, does not follow a course like responses to
conventional antigens such as viruses, but accelerates as glucose tolerance deteriorates. To
identify the unique features of the autoimmune effectors that may explain this behavior, we
analyzed diabetogenic CD8+ T cells that recognize a peptide from the diabetes antigen
IGRP (NRP-V7-reactive) in prediabetic NOD mice and compared them to others that shared …