A brief history of T cell help to B cells

S Crotty - Nature Reviews Immunology, 2015 - nature.com
Nature Reviews Immunology, 2015nature.com
In celebration of the 50th anniversary of the discovery of B cells, I take a look back at the
history of T cell help to B cells, which was discovered 47 years ago. In addition, I summarize
and categorize the distinct molecules that are expressed by CD4+ T cells that
constitute'help'to B cells, and particularly the molecules expressed by T follicular helper
(TFH) cells, which are the specialized providers of help to B cells.
Abstract
In celebration of the 50th anniversary of the discovery of B cells, I take a look back at the history of T cell help to B cells, which was discovered 47 years ago. In addition, I summarize and categorize the distinct molecules that are expressed by CD4+ T cells that constitute 'help' to B cells, and particularly the molecules expressed by T follicular helper (TFH) cells, which are the specialized providers of help to B cells.
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