Albuminuria is not an appropriate therapeutic target in patients with CKD: the con view
LF Fried, J Lewis - Clinical Journal of the American Society of …, 2015 - journals.lww.com
Albuminuria is a risk factor for progression of kidney disease. Angiotensin-converting
enzyme inhibitors or angiotensin receptor blockers slow the progression to ESRD, an effect
that is correlated with reduction in albuminuria. This has led to the hypothesis that
albuminuria should be a target for therapy. This work argues that there are issues with this
hypothesis. The previously reported studies were not designed to test the hypothesis that
achieving a specific albuminuria target would be beneficial in and of itself irrespective the …
enzyme inhibitors or angiotensin receptor blockers slow the progression to ESRD, an effect
that is correlated with reduction in albuminuria. This has led to the hypothesis that
albuminuria should be a target for therapy. This work argues that there are issues with this
hypothesis. The previously reported studies were not designed to test the hypothesis that
achieving a specific albuminuria target would be beneficial in and of itself irrespective the …