[HTML][HTML] Oligomerization and membrane-binding properties of covalent adducts formed by the interaction of α-synuclein with the toxic dopamine metabolite 3, 4 …
C Follmer, E Coelho-Cerqueira… - Journal of Biological …, 2015 - ASBMB
Oxidative deamination of dopamine produces the highly toxic aldehyde 3, 4-
dihydroxyphenylacetaldehyde (DOPAL), enhanced production of which is found in post-
mortem brains of Parkinson disease patients. When injected into the substantia nigra of rat
brains, DOPAL causes the loss of dopaminergic neurons accompanied by the accumulation
of potentially toxic oligomers of the presynaptic protein α-synuclein (aS), potentially
explaining the synergistic toxicity described for dopamine metabolism and aS aggregation …
dihydroxyphenylacetaldehyde (DOPAL), enhanced production of which is found in post-
mortem brains of Parkinson disease patients. When injected into the substantia nigra of rat
brains, DOPAL causes the loss of dopaminergic neurons accompanied by the accumulation
of potentially toxic oligomers of the presynaptic protein α-synuclein (aS), potentially
explaining the synergistic toxicity described for dopamine metabolism and aS aggregation …