Accumulation of 3, 4-dihydroxyphenylglycolaldehyde, the neurotoxic monoamine oxidase A metabolite of norepinephrine, in locus ceruleus cell bodies in Alzheimer's …
WJ Burke, SW Li, CA Schmitt, P Xia, HD Chung… - Brain research, 1999 - Elsevier
WJ Burke, SW Li, CA Schmitt, P Xia, HD Chung, KN Gillespie
Brain research, 1999•Elsevier3, 4-Dihydroxyphenylglycolaldehyde (DOPEGAL) is the neurotoxic monoamine oxidase A
(MAO-A) metabolite of norepinephrine (NE). NE neurons in the locus ceruleus (LC) die in
Alzheimer's disease (AD). To determine if DOPEGAL could contribute to NE neuron death in
AD we measured levels of DOPEGAL, NE and their synthesizing enzymes in LC from AD
and matched controls. We found 2.8-and 3.6-fold increases in DOPEGAL and MAO-A in AD
LC neuronal cell bodies compared to controls. NE and dopamine β-hydroxylase were …
(MAO-A) metabolite of norepinephrine (NE). NE neurons in the locus ceruleus (LC) die in
Alzheimer's disease (AD). To determine if DOPEGAL could contribute to NE neuron death in
AD we measured levels of DOPEGAL, NE and their synthesizing enzymes in LC from AD
and matched controls. We found 2.8-and 3.6-fold increases in DOPEGAL and MAO-A in AD
LC neuronal cell bodies compared to controls. NE and dopamine β-hydroxylase were …
3,4-Dihydroxyphenylglycolaldehyde (DOPEGAL) is the neurotoxic monoamine oxidase A (MAO-A) metabolite of norepinephrine (NE). NE neurons in the locus ceruleus (LC) die in Alzheimer's disease (AD). To determine if DOPEGAL could contribute to NE neuron death in AD we measured levels of DOPEGAL, NE and their synthesizing enzymes in LC from AD and matched controls. We found 2.8- and 3.6-fold increases in DOPEGAL and MAO-A in AD LC neuronal cell bodies compared to controls. NE and dopamine β-hydroxylase were increased by 3.8- and 10.7-fold, respectively. Implications for the mechanism of neuron death in AD are discussed.
Elsevier