Nucleus locus ceruleus: new evidence of anatomical and physiological specificity

SL Foote, FE Bloom, G Aston-Jones - Physiological reviews, 1983 - journals.physiology.org
SL Foote, FE Bloom, G Aston-Jones
Physiological reviews, 1983journals.physiology.org
In the 5 years since Amaral and Sinnamon's (12) comprehensive review of the neurobiology
of the locus ceruleus (LC), there has been substantial progress in characterizing the
anatomy and physiology of these norepinephrine (NE)-containing neurons. Our review
summarizes the most important of these developments and synthesizes them, along with
previous knowledge, into working hypotheses concerning the physiological functions of
these noradrenergic neurons of the LC (denoted in this review by LC-NE). We have selected …
In the 5 years since Amaral and Sinnamon’s (12) comprehensive review of the neurobiology of the locus ceruleus (LC), there has been substantial progress in characterizing the anatomy and physiology of these norepinephrine (NE)-containing neurons. Our review summarizes the most important of these developments and synthesizes them, along with previous knowledge, into working hypotheses concerning the physiological functions of these noradrenergic neurons of the LC (denoted in this review by LC-NE). We have selected data relevant to four basic characteristics of the LC system for detailed review and interpretation: 1) electrophysiological data indicating
American Physiological Society