[HTML][HTML] The Novel Anticonvulsant Drug, Gabapentin (Neurontin), Binds to the α2δ Subunit of a Calcium Channel (∗)

NS Gee, JP Brown, VUK Dissanayake, J Offord… - Journal of Biological …, 1996 - ASBMB
Gabapentin (1-(aminomethyl) cyclohexane acetic acid; Neurontin) is a novel anticonvulsant
drug, with a mechanism of action apparently dissimilar to that of other antiepileptic agents.
We report here the isolation and characterization of a [3 H] gabapentin-binding protein from
pig cerebral cortex membranes. The detergent-solubilized binding protein was purified 1022-
fold, in a six-step column-chromatographic procedure, with a yield of 3.9%. The purified
protein had an apparent subunit M r of 130,000, and was heavily glycosylated. The partial N …