Measurement and estimation of GFR in children and adolescents
GJ Schwartz, DF Work - Clinical Journal of the American Society of …, 2009 - journals.lww.com
GFR is the best indicator of renal function in children and adolescents and is critical for
diagnosing acute and chronic kidney impairment, intervening early to prevent end-stage
renal failure, prescribing nephrotoxic drugs and drugs cleared by a failing kidney, and
monitoring for side effects of medications. Renal inulin clearance was the gold standard for
GFR but is compromised by lack of availability, difficult assays, and problems of collecting
timed urine samples, especially in children with vesicoureteral reflux or bladder dysfunction …
diagnosing acute and chronic kidney impairment, intervening early to prevent end-stage
renal failure, prescribing nephrotoxic drugs and drugs cleared by a failing kidney, and
monitoring for side effects of medications. Renal inulin clearance was the gold standard for
GFR but is compromised by lack of availability, difficult assays, and problems of collecting
timed urine samples, especially in children with vesicoureteral reflux or bladder dysfunction …