Glutaminases in slowly proliferating gastroenteropancreatic neuroendocrine neoplasms/tumors (GEP-NETs): Selective overexpression of mRNA coding for the KGA …
M Szeliga, J Ćwikła, M Obara-Michlewska… - Experimental and …, 2016 - Elsevier
Glutamine (Gln) is a crucial metabolite in cancer cells of different origin, and the expression
and activity of different isoforms of the Gln-degrading enzyme, glutaminase (GA), have
variable implications for tumor growth and metabolism. Human glutaminases are encoded
by two genes: the GLS gene encodes the kidney-type glutaminases, KGA and GAC, while
the GLS2 gene encodes the liver-type glutaminases, GAB and LGA. Recent studies suggest
that the GAC isoform and thus high GAC/KGA ratio, are characteristic of highly proliferating …
and activity of different isoforms of the Gln-degrading enzyme, glutaminase (GA), have
variable implications for tumor growth and metabolism. Human glutaminases are encoded
by two genes: the GLS gene encodes the kidney-type glutaminases, KGA and GAC, while
the GLS2 gene encodes the liver-type glutaminases, GAB and LGA. Recent studies suggest
that the GAC isoform and thus high GAC/KGA ratio, are characteristic of highly proliferating …