Embolization of hepatocellular carcinoma with drug-eluting beads: doxorubicin tissue concentration and distribution in patient liver explants

J Namur, SJ Citron, MT Sellers, MH Dupuis… - Journal of …, 2011 - Elsevier
BACKGROUND & AIMS: To follow the local tissue delivery of doxorubicin in HCC explants
from patients embolized with drug-eluting beads and to compare it with histologic
modifications. METHODS: Six patients with HCC underwent chemoembolization with
doxorubicin-eluting beads (caliber 100–300μm, dose 75–150mg) followed by liver
transplantation at different time points (8h to 36days). On sections of the explanted liver, the
tissue concentration of doxorubicin was determined radially around bead-occluded vessels …