Failure to restore the Vγ2-Jγ1. 2 repertoire in HIV-infected men receiving highly active antiretroviral therapy (HAART)
AM Hebbeler, N Propp, C Cairo, H Li, JS Cummings… - Clinical …, 2008 - Elsevier
Gammadelta (γδ) T cells expressing the Vγ2-Jγ1. 2Vδ2 (Vγ9-JPVδ2, alternate
nomenclature) T cell receptor (TCR) constitute the major peripheral blood population of γδ T
cells in adult humans and are specifically depleted during human immunodeficiency virus
(HIV) disease. Vγ2-Jγ1. 2Vδ2 T cells provide a convenient model for assessing the impact of
antiretroviral therapy on cell populations that are not susceptible to direct infection because
they do not express CD4 and depletion occurs by indirect mechanisms. We obtained …
nomenclature) T cell receptor (TCR) constitute the major peripheral blood population of γδ T
cells in adult humans and are specifically depleted during human immunodeficiency virus
(HIV) disease. Vγ2-Jγ1. 2Vδ2 T cells provide a convenient model for assessing the impact of
antiretroviral therapy on cell populations that are not susceptible to direct infection because
they do not express CD4 and depletion occurs by indirect mechanisms. We obtained …