NKT and MAIT invariant TCRα sequences can be produced efficiently by VJ gene recombination
HY Greenaway, B Ng, DA Price, DC Douek… - Immunobiology, 2013 - Elsevier
Semi-invariant T cell receptors (TCRs) found on natural killer T (NKT) and mucosal-
associated invariant T (MAIT) cells are characterized by the use of invariant variable (V) and
joining (J) gene combinations in the TCR α-chain, as well as ubiquitous canonical TCRα
amino acid sequences that are dominant in many individuals and similar across species.
That they are so prevalent indicates that they occupy an important niche within the immune
system. However, these TCRs are produced by a largely random gene recombination …
associated invariant T (MAIT) cells are characterized by the use of invariant variable (V) and
joining (J) gene combinations in the TCR α-chain, as well as ubiquitous canonical TCRα
amino acid sequences that are dominant in many individuals and similar across species.
That they are so prevalent indicates that they occupy an important niche within the immune
system. However, these TCRs are produced by a largely random gene recombination …