Tissue Factor–Factor VIIa complex induces cytokine expression in coronary artery smooth muscle cells
G Demetz, I Seitz, A Stein, B Steppich, P Groha… - Atherosclerosis, 2010 - Elsevier
OBJECTIVE: Within atherosclerotic lesions Tissue Factor (TF)–Factor VIIa (FVIIa) not only
contributes to thrombotic events but also alters vascular remodeling through enhancement
of migration. Moreover, the TF–FVIIa–FXa complex activates protease-activated receptors
(PAR). TF/FVIIa/PAR-2 signaling has also been shown to promote proliferation and
metastasis of tumor cells. Since coagulation factors promote inflammation which plays a
major role during atherosclerosis as well as tumor metastasis this study sought to investigate …
contributes to thrombotic events but also alters vascular remodeling through enhancement
of migration. Moreover, the TF–FVIIa–FXa complex activates protease-activated receptors
(PAR). TF/FVIIa/PAR-2 signaling has also been shown to promote proliferation and
metastasis of tumor cells. Since coagulation factors promote inflammation which plays a
major role during atherosclerosis as well as tumor metastasis this study sought to investigate …