[HTML][HTML] Membrane raft association of CD47 is necessary for actin polymerization and protein kinase C θ translocation in its synergistic activation of T cells
RA Rebres, JM Green, MI Reinhold, M Ticchioni… - Journal of Biological …, 2001 - ASBMB
CD47 is a ubiquitously expressed membrane protein with an extracellular Ig domain and a
multiple membrane-spanning domain that can synergize with antigen to induce interleukin
(IL)-2 secretion by T lymphocytes. Ligation of CD47 induced actin polymerization and
increased protein kinase Cθ (PKCθ) association with the cytoskeleton independent of
antigen receptor ligation, but ligation of mutant forms of the molecule missing either the Ig
domain or the multiple membrane-spanning domain did not. Simultaneous ligation of CD47 …
multiple membrane-spanning domain that can synergize with antigen to induce interleukin
(IL)-2 secretion by T lymphocytes. Ligation of CD47 induced actin polymerization and
increased protein kinase Cθ (PKCθ) association with the cytoskeleton independent of
antigen receptor ligation, but ligation of mutant forms of the molecule missing either the Ig
domain or the multiple membrane-spanning domain did not. Simultaneous ligation of CD47 …