[PDF][PDF] Using genome-scale models to predict biological capabilities
EJ O'Brien, JM Monk, BO Palsson - Cell, 2015 - cell.com
EJ O'Brien, JM Monk, BO Palsson
Cell, 2015•cell.comConstraint-based reconstruction and analysis (COBRA) methods at the genome scale have
been under development since the first whole-genome sequences appeared in the mid-
1990s. A few years ago, this approach began to demonstrate the ability to predict a range of
cellular functions, including cellular growth capabilities on various substrates and the effect
of gene knockouts at the genome scale. Thus, much interest has developed in
understanding and applying these methods to areas such as metabolic engineering …
been under development since the first whole-genome sequences appeared in the mid-
1990s. A few years ago, this approach began to demonstrate the ability to predict a range of
cellular functions, including cellular growth capabilities on various substrates and the effect
of gene knockouts at the genome scale. Thus, much interest has developed in
understanding and applying these methods to areas such as metabolic engineering …
Constraint-based reconstruction and analysis (COBRA) methods at the genome scale have been under development since the first whole-genome sequences appeared in the mid-1990s. A few years ago, this approach began to demonstrate the ability to predict a range of cellular functions, including cellular growth capabilities on various substrates and the effect of gene knockouts at the genome scale. Thus, much interest has developed in understanding and applying these methods to areas such as metabolic engineering, antibiotic design, and organismal and enzyme evolution. This Primer will get you started.
cell.com