[HTML][HTML] c-Kit and stem cell factor regulate PANC-1 cell differentiation into insulin-and glucagon-producing cells

Y Wu, J Li, S Saleem, SP Yee, AA Hardikar… - Laboratory …, 2010 - Elsevier
Recent evidence has shown that stem cell factor (SCF) and its receptor, c-Kit, have an
important role in pancreatic islet development by promoting islet cell differentiation and
proliferation. In this study, we examined the role of c-Kit and SCF in the differentiation and
proliferation of insulin-and glucagon-producing cells using a human pancreatic duct cell line
(PANC-1). Our study showed that increased expression of endocrine cell markers (such as
insulin and glucagon) and transcription factors (such as PDX-1 and PAX-6) coincided with a …