Restenosis is the principal drawback of percutaneous coronary procedures. Until now, the
only widely accepted way to reduce restenosis rate has been the stent. However, clinical
restenosis still represents the major limitation of this technology. This article summarizes
recent laboratory and clinical investigations concerning the mechanisms responsible for the
transmission of mitogenic signals from plasma membrane to the nucleus in vascular smooth
muscle cells that determine neointima formation after stent deployment. Recent …