Opposing T cell responses in experimental autoimmune encephalomyelitis

N Saligrama, F Zhao, MJ Sikora, WS Serratelli… - Nature, 2019 - nature.com
N Saligrama, F Zhao, MJ Sikora, WS Serratelli, RA Fernandes, DM Louis, W Yao, X Ji
Nature, 2019nature.com
Experimental autoimmune encephalomyelitis is a model for multiple sclerosis. Here we
show that induction generates successive waves of clonally expanded CD4+, CD8+ and γδ+
T cells in the blood and central nervous system, similar to gluten-challenge studies of
patients with coeliac disease. We also find major expansions of CD8+ T cells in patients with
multiple sclerosis. In autoimmune encephalomyelitis, we find that most expanded CD4+ T
cells are specific for the inducing myelin peptide MOG35–55. By contrast, surrogate peptides …
Abstract
Experimental autoimmune encephalomyelitis is a model for multiple sclerosis. Here we show that induction generates successive waves of clonally expanded CD4+, CD8+ and γδ+ T cells in the blood and central nervous system, similar to gluten-challenge studies of patients with coeliac disease. We also find major expansions of CD8+ T cells in patients with multiple sclerosis. In autoimmune encephalomyelitis, we find that most expanded CD4+ T cells are specific for the inducing myelin peptide MOG35–55. By contrast, surrogate peptides derived from a yeast peptide major histocompatibility complex library of some of the clonally expanded CD8+ T cells inhibit disease by suppressing the proliferation of MOG-specific CD4+ T cells. These results suggest that the induction of autoreactive CD4+ T cells triggers an opposing mobilization of regulatory CD8+ T cells.
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