Disease exacerbation of multiple sclerosis is characterized by loss of terminally differentiated autoregulatory CD8+ T cells
K Cunnusamy, EJ Baughman, J Franco, SB Ortega… - Clinical …, 2014 - Elsevier
Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous
system (CNS). Although its etiology remains unknown, pathogenic T cells are thought to
underlie MS immune pathology. We recently showed that MS patients harbor CNS-specific
CD8+ Tregs that are deficient during disease relapse. We now demonstrate that CNS-
specific CD8+ Tregs were cytolytic and could eliminate pathogenic CD4+ T cells. These
CD8+ Tregs were present primarily in terminally differentiated (CD27−, CD45RO−) subset …
system (CNS). Although its etiology remains unknown, pathogenic T cells are thought to
underlie MS immune pathology. We recently showed that MS patients harbor CNS-specific
CD8+ Tregs that are deficient during disease relapse. We now demonstrate that CNS-
specific CD8+ Tregs were cytolytic and could eliminate pathogenic CD4+ T cells. These
CD8+ Tregs were present primarily in terminally differentiated (CD27−, CD45RO−) subset …