Frequency of circulating autoreactive T cells committed to myelin determinants in relapsing–remitting multiple sclerosis patients
AE Ngono, S Pettré, M Salou, B Bahbouhi… - Clinical …, 2012 - Elsevier
Multiple sclerosis (MS) is considered as an autoimmune disease in which T cell reactivity to
self-antigens expressed in the brain, particularly myelin antigens, plays a pivotal role.
Various myelin-derived peptides, including peptides of myelin basic protein (MBP),
proteolipid protein (PLP) and myelin oligodendrocyte glycoprotein (MOG) have been studied
as putative target in MS. However, CD4+ and CD8+ T cells recognizing autoantigens from
brain have been detected in the blood of MS patients as well as the blood of normal …
self-antigens expressed in the brain, particularly myelin antigens, plays a pivotal role.
Various myelin-derived peptides, including peptides of myelin basic protein (MBP),
proteolipid protein (PLP) and myelin oligodendrocyte glycoprotein (MOG) have been studied
as putative target in MS. However, CD4+ and CD8+ T cells recognizing autoantigens from
brain have been detected in the blood of MS patients as well as the blood of normal …