c-myc amplification is associated with HER2 amplification and closely linked with cell proliferation in tissue microarray of nonselected breast cancers
K Park, K Kwak, J Kim, S Lim, S Han - Human pathology, 2005 - Elsevier
c-myc and HER2 amplification were analyzed on 214 consecutive breast cancers by
fluorescence in situ hybridization using tissue microarray technology. The frequencies of
amplification were 15.4%(33/214) and 23.3%(49/210), respectively. c-myc amplification was
significantly associated with HER2 amplification (P<. 001) and closely linked with cell
proliferative activity, measured by Ki67 labeling index (P=. 010). In univariate survival
analysis, lymph node status, tumor size, and histological grade were significant prognostic …
fluorescence in situ hybridization using tissue microarray technology. The frequencies of
amplification were 15.4%(33/214) and 23.3%(49/210), respectively. c-myc amplification was
significantly associated with HER2 amplification (P<. 001) and closely linked with cell
proliferative activity, measured by Ki67 labeling index (P=. 010). In univariate survival
analysis, lymph node status, tumor size, and histological grade were significant prognostic …