[HTML][HTML] P2Y6 nucleotide receptor mediates monocyte interleukin-8 production in response to UDP or lipopolysaccharide
Extracellular nucleotides are autocrine and paracrine cellular mediators that signal through
P2 nucleotide receptors. Monocytic cells express several P2Y receptors but the role of these
G protein-coupled receptors in monocytes is not known. Here, we present evidence that P2Y
6 regulates chemokine production and release in monocytes. We find that UDP, a selective
P2Y 6 agonist, stimulates interleukin (IL)-8 release in human THP-1 monocytic cells
whereas other nucleotides are relatively inactive. P2 receptor antagonists or P2Y 6 …
P2 nucleotide receptors. Monocytic cells express several P2Y receptors but the role of these
G protein-coupled receptors in monocytes is not known. Here, we present evidence that P2Y
6 regulates chemokine production and release in monocytes. We find that UDP, a selective
P2Y 6 agonist, stimulates interleukin (IL)-8 release in human THP-1 monocytic cells
whereas other nucleotides are relatively inactive. P2 receptor antagonists or P2Y 6 …