[HTML][HTML] Promises, promises, and precision medicine
In 1999 Francis Collins published a foundational document of precision medicine entitled
“Medical and Societal Consequences of the Human Genome Project,”(1) which made
predictions about the ways the human genome would be used to predict, prevent, and treat
disease in 2010. In 2000, he suggested that “Over the longer term, perhaps in another 15 or
20 years, you will see a complete transformation in therapeutic medicine”(2). The vision
described in the article became the aspirational template for the precision medicine …
“Medical and Societal Consequences of the Human Genome Project,”(1) which made
predictions about the ways the human genome would be used to predict, prevent, and treat
disease in 2010. In 2000, he suggested that “Over the longer term, perhaps in another 15 or
20 years, you will see a complete transformation in therapeutic medicine”(2). The vision
described in the article became the aspirational template for the precision medicine …
In 1999 Francis Collins published a foundational document of precision medicine entitled “Medical and Societal Consequences of the Human Genome Project,”(1) which made predictions about the ways the human genome would be used to predict, prevent, and treat disease in 2010. In 2000, he suggested that “Over the longer term, perhaps in another 15 or 20 years, you will see a complete transformation in therapeutic medicine”(2).
The vision described in the article became the aspirational template for the precision medicine movement (Figure 1). We have passed the 2010 deadline and are rapidly approaching 2020, yet the “complete transformation in therapeutic medicine” has not occurred. Using the framework of the predictions made nearly 20 years ago, we argue that the foundational assumptions of precision medicine are unsound.
The Journal of Clinical Investigation