Aberrant glycosylation in tumors and tumor-associated carbohydrate antigens

S Hakomori - Advances in cancer research, 1989 - Elsevier
Publisher Summary Aberrant glycosylation is the most common phenomenon associated
with oncogenic transformation expressed in cell membranes of animal and human cancer
cells. Such aberrant structures at the surface membranes may well be effective targets in
prevention, diagnosis, and treatment of human cancer. Many of the aberrant glycosylation
products can be recognized by specific MAbs as tumor-associated carbohydrate antigens.
Many of these antigens have been identified as carbohydrates, thus there is increasing …