Molecular mechanisms and functional implications of polarized actin remodeling at the T cell immunological synapse

A Le Floc'h, M Huse - Cellular and molecular life sciences, 2015 - Springer
Cellular and molecular life sciences, 2015Springer
Transient, specialized cell–cell interactions play a central role in leukocyte function by
enabling specific intercellular communication in the context of a highly dynamic systems
level response. The dramatic structural changes required for the formation of these contacts
are driven by rapid and precise cytoskeletal remodeling events. In recent years, the
immunological synapse that forms between a T lymphocyte and its antigen-presenting target
cell has emerged as an important model system for understanding immune cell interactions …
Abstract
Transient,specialized cell–cell interactions play a central role in leukocyte function by enabling specific intercellular communication in the context of a highly dynamic systems level response. The dramatic structural changes required for the formation of these contacts are driven by rapid and precise cytoskeletal remodeling events. In recent years, the immunological synapse that forms between a T lymphocyte and its antigen-presenting target cell has emerged as an important model system for understanding immune cell interactions. In this review, we discuss how regulators of the cortical actin cytoskeleton control synaptic architecture and in this way specify T cell function.
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