New insights into the regulation and cellular functions of the ARP2/3 complex
JD Rotty, C Wu, JE Bear - Nature reviews Molecular cell biology, 2013 - nature.com
JD Rotty, C Wu, JE Bear
Nature reviews Molecular cell biology, 2013•nature.comAbstract The actin-related protein 2/3 (ARP2/3) complex nucleates branched actin filament
networks, but requires nucleation promoting factors (NPFs) to stimulate this activity. NPFs
include proteins such as Wiskott–Aldrich syndrome protein (WASP), neural WASP (NWASP),
WASP family verprolin-homologous protein (WAVE; also known as SCAR) and the recently
identified WASP and SCAR homologue (WASH) complex. The mechanisms underlying NPF-
dependent regulation and the cellular functions of ARP2/3 are being unravelled using new …
networks, but requires nucleation promoting factors (NPFs) to stimulate this activity. NPFs
include proteins such as Wiskott–Aldrich syndrome protein (WASP), neural WASP (NWASP),
WASP family verprolin-homologous protein (WAVE; also known as SCAR) and the recently
identified WASP and SCAR homologue (WASH) complex. The mechanisms underlying NPF-
dependent regulation and the cellular functions of ARP2/3 are being unravelled using new …
Abstract
The actin-related protein 2/3 (ARP2/3) complex nucleates branched actin filament networks, but requires nucleation promoting factors (NPFs) to stimulate this activity. NPFs include proteins such as Wiskott–Aldrich syndrome protein (WASP), neural WASP (NWASP), WASP family verprolin-homologous protein (WAVE; also known as SCAR) and the recently identified WASP and SCAR homologue (WASH) complex. The mechanisms underlying NPF-dependent regulation and the cellular functions of ARP2/3 are being unravelled using new chemical and genetic approaches. Of particular interest is the role of the ARP2/3 complex in vesicular trafficking and directional cell motility.
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