Interferon-α and cancer: mechanisms of action and new perspectives of clinical use
M Ferrantini, I Capone, F Belardelli - Biochimie, 2007 - Elsevier
Interferons-α (IFN-α) are pleiotropic cytokines belonging to type I IFNs, extensively used in
the treatment of patients with some types of cancer and viral disease. IFN-α can affect tumor
cell functions by multiple mechanisms. In addition, these cytokines can promote the
differentiation and activity of host immune cells. Early studies in mouse tumor models
showed the importance of host immune mechanisms in the generation of a long-lasting
antitumor response after treatment of the animals with IFN-α/β. Subsequently, an ensemble …
the treatment of patients with some types of cancer and viral disease. IFN-α can affect tumor
cell functions by multiple mechanisms. In addition, these cytokines can promote the
differentiation and activity of host immune cells. Early studies in mouse tumor models
showed the importance of host immune mechanisms in the generation of a long-lasting
antitumor response after treatment of the animals with IFN-α/β. Subsequently, an ensemble …