Severity and frequency of proximal tubule injury determines renal prognosis

K Takaori, J Nakamura, S Yamamoto… - Journal of the …, 2016 - journals.lww.com
AKI increases the risk of developing CKD, but the mechanisms linking AKI to CKD remain
unclear. Because proximal tubule injury is the mainstay of AKI, we postulated that proximal
tubule injury triggers features of CKD. We generated a novel mouse model to induce
proximal tubule–specific adjustable injury by inducing the expression of diphtheria toxin
(DT) receptor with variable prevalence in proximal tubules. Administration of high-dose DT
in mice expressing the DT receptor consistently caused severe proximal tubule–specific …