Increased cardiovascular disease risk in the HIV-positive population on ART: potential role of HIV-Nef and Tat

T Wang, R Yi, LA Green, S Chelvanambi… - Cardiovascular …, 2015 - Elsevier
With effective antiretroviral therapy (ART), many HIV-infected people die of diseases other
than acquired immune deficiency syndrome (AIDS). In particular, coronary artery disease
has emerged as one of most critical complications of HIV infection and a major cause of
morbidity and mortality. Although reportedly antiretroviral combination therapy itself may
accelerate atherosclerosis by enhancing dyslipidemia, most recent epidemiological studies
support the notion that HIV infection itself contributes to cardiovascular disease. However, it …