[HTML][HTML] Ubiquitination regulates expression of the serine/arginine-rich splicing factor 1 (SRSF1) in normal and systemic lupus erythematosus (SLE) T cells
VR Moulton, AR Gillooly, GC Tsokos - Journal of Biological Chemistry, 2014 - ASBMB
T cells from patients with systemic lupus erythematosus (SLE) exhibit reduced expression of
the critical T cell receptor (TCR)-associated CD3ζ signaling chain and are poor producers of
the vital cytokine IL-2. By oligonucleotide pulldown and mass spectrometry discovery
approaches, we identified the splicing regulator serine/arginine-rich splicing factor (SRSF) 1
or splicing factor 2/alternative splicing factor (SF2/ASF) to be important in the expression of
CD3ζ chain. Importantly, increases in the expression of SRSF1 rescued IL-2 production in T …
the critical T cell receptor (TCR)-associated CD3ζ signaling chain and are poor producers of
the vital cytokine IL-2. By oligonucleotide pulldown and mass spectrometry discovery
approaches, we identified the splicing regulator serine/arginine-rich splicing factor (SRSF) 1
or splicing factor 2/alternative splicing factor (SF2/ASF) to be important in the expression of
CD3ζ chain. Importantly, increases in the expression of SRSF1 rescued IL-2 production in T …