Gender and the progression of renal disease

SL Seliger, C Davis… - Current opinion in …, 2001 - journals.lww.com
SL Seliger, C Davis, C Stehman-Breen
Current opinion in nephrology and hypertension, 2001journals.lww.com
Many studies of chronic renal disease have reported that men have a more rapid
progression of renal insufficiency. However, other studies have found no differences
between the sexes, and the true effect of sex on chronic renal disease remains a topic of
controversy. There is evidence that women with non-diabetic renal diseases experience a
slower progression, but in diabetic renal disease, the effect of gender is not yet established.
Sex hormones may mediate the effects of gender on chronic renal disease, through …
Abstract
Many studies of chronic renal disease have reported that men have a more rapid progression of renal insufficiency. However, other studies have found no differences between the sexes, and the true effect of sex on chronic renal disease remains a topic of controversy. There is evidence that women with non-diabetic renal diseases experience a slower progression, but in diabetic renal disease, the effect of gender is not yet established. Sex hormones may mediate the effects of gender on chronic renal disease, through alterations in the renin-angiotensin system, reduction in mesangial collagen synthesis, the modification of collagen degradation, and upregulation of nitric oxide synthesis.
Lippincott Williams & Wilkins