[HTML][HTML] The intestinal metal transporter ZIP14 maintains systemic manganese homeostasis
IF Scheiber, Y Wu, SE Morgan, N Zhao - Journal of Biological Chemistry, 2019 - ASBMB
ZIP14 (encoded by the solute carrier 39 family member 14 (SLC39A14) gene) is a
manganese transporter that is abundantly expressed in the liver and small intestine. Loss-of-
function mutations in SLC39A14 cause severe hypermanganesemia. Because the liver is
regarded as the main regulatory organ involved in manganese homeostasis, impaired
hepatic manganese uptake for subsequent biliary excretion has been proposed as the
underlying disease mechanism. However, liver-specific Zip14 KO mice exhibit decreased …
manganese transporter that is abundantly expressed in the liver and small intestine. Loss-of-
function mutations in SLC39A14 cause severe hypermanganesemia. Because the liver is
regarded as the main regulatory organ involved in manganese homeostasis, impaired
hepatic manganese uptake for subsequent biliary excretion has been proposed as the
underlying disease mechanism. However, liver-specific Zip14 KO mice exhibit decreased …