Brain structure in preclinical Huntington's disease

JS Paulsen, VA Magnotta, AE Mikos, HL Paulson… - Biological …, 2006 - Elsevier
BACKGROUND: Huntington's disease (HD) is traditionally conceptualized as a
degenerative disease of the striatum. Recent scientific advances, however, have suggested
neurodevelopmental contributions and extrastriatal brain abnormalities. This study was
designed to assess the morphology of the brain in participants who had previously
undergone elective DNA analyses for the HD mutation who did not currently have a clinical
diagnosis of HD (preclinical HD subjects). METHODS: Twenty-four preclinical participants …