Autophagy is a functionally conserved self-degradation process that facilitates the survival of
eukaryotic life via the management of cellular bioenergetics and maintenance of the fidelity
of genomic DNA. The first known autophagy inducer was Beclin-1. Beclin-1 is expressed in
multicellular eukaryotes ranging throughout plants to animals, comprising a nonmonophyllic
group, as shown in this report via aggressive BLAST searches. In humans, Beclin-1 is a
haploinsuffient tumor suppressor as biallelic deletions have not been observed in patient …