[HTML][HTML] Role of cAMP-responsive element-binding protein (CREB)-regulated transcription coactivator 3 (CRTC3) in the initiation of mitochondrial biogenesis and …
TA Than, H Lou, C Ji, S Win, N Kaplowitz - Journal of Biological Chemistry, 2011 - ASBMB
Peroxisome proliferator-activated receptor α, coactivator 1α (PGC-1α) is the master regulator
of mitochondrial biogenesis. PGC-1α expression is under the control of the transcription
factor, cAMP-responsive element-binding protein (CREB). In searching for candidate
transcription factors that mediate mitochondrial stress-initiated mitochondria-to-nucleus
signaling in the regulation of mitochondrial biogenesis, we assessed the effect of silencing
CREB-regulated transcription co-activators (CRTC). CRTC isoforms are co-activators of …
of mitochondrial biogenesis. PGC-1α expression is under the control of the transcription
factor, cAMP-responsive element-binding protein (CREB). In searching for candidate
transcription factors that mediate mitochondrial stress-initiated mitochondria-to-nucleus
signaling in the regulation of mitochondrial biogenesis, we assessed the effect of silencing
CREB-regulated transcription co-activators (CRTC). CRTC isoforms are co-activators of …