[HTML][HTML] c-Jun N-terminal kinase (JNK)-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF) requires mitochondrial Sab protein expression …

S Win, TA Than, D Han, LM Petrovic… - Journal of Biological …, 2011 - ASBMB
Sustained JNK activation plays a critical role in hepatotoxicity by acetaminophen or
GalN/TNF-α. To address the importance of JNK translocation to mitochondria that
accompanies sustained activation in these models, we assessed the importance of the
expression of a potential initial target of JNK in the outer membrane of mitochondria, namely
Sab (SH3 domain-binding protein that preferentially associates with Btk), also known as
Sh3bp5 (SH3 domain-binding protein 5). Silencing the expression of Sab in the liver using …