Metabolic pathways involved in lactate metabolism are important to understand the
physiological response to exercise and the pathogenesis of prevalent diseases such as
diabetes and cancer. Monocarboxylate transporters are being investigated as potential
targets for diagnosis and therapy of these and other disorders. Glucose and alanine produce
pyruvate which is reduced to lactate by lactate dehydrogenase in the cytoplasm without
oxygen consumption. Lactate removal takes place via its oxidation to pyruvate by lactate …