[HTML][HTML] The Pol32 subunit of DNA polymerase δ contains separable domains for processive replication and proliferating cell nuclear antigen (PCNA) binding
E Johansson, P Garg, PMJ Burgers - Journal of Biological Chemistry, 2004 - ASBMB
We have carried out a domain analysis of POL32, the third subunit of Saccharomyces
cerevisiae DNA polymerase δ (Pol δ). Interactions with POL31, the second subunit of Pol δ,
are specified by the amino-terminal 92 amino acids, whereas interactions with the
replication clamp proliferating cell nuclear antigen (PCNA, POL30) reside at the extreme
carboxyl-terminal region. Pol32 binding, in vivo and in vitro, to the large subunit of DNA
polymerase α, POL1, requires the carboxyl-proximal region of Pol32. The amino-terminal …
cerevisiae DNA polymerase δ (Pol δ). Interactions with POL31, the second subunit of Pol δ,
are specified by the amino-terminal 92 amino acids, whereas interactions with the
replication clamp proliferating cell nuclear antigen (PCNA, POL30) reside at the extreme
carboxyl-terminal region. Pol32 binding, in vivo and in vitro, to the large subunit of DNA
polymerase α, POL1, requires the carboxyl-proximal region of Pol32. The amino-terminal …