Presynaptic inhibition of gamma-aminobutyric acid release in the bed nucleus of the stria terminalis by kappa opioid receptor signaling
C Li, KE Pleil, AM Stamatakis, S Busan, L Vong… - Biological …, 2012 - Elsevier
BACKGROUND: The kappa opioid receptor (KOR) and its endogenous agonist, the
neuropeptide dynorphin, are a critical component of the central stress system. Both
dynorphin and KOR are expressed in the bed nucleus of the stria terminalis (BNST), a brain
region associated with anxiety and stress. This suggests that KOR activation in this region
may play a role in the regulation of emotional behaviors. To date, however, there has been
no investigation of the ability of KOR to modulate synaptic transmission in the BNST …
neuropeptide dynorphin, are a critical component of the central stress system. Both
dynorphin and KOR are expressed in the bed nucleus of the stria terminalis (BNST), a brain
region associated with anxiety and stress. This suggests that KOR activation in this region
may play a role in the regulation of emotional behaviors. To date, however, there has been
no investigation of the ability of KOR to modulate synaptic transmission in the BNST …