[HTML][HTML] Delta rhythmicity is a reliable EEG biomarker in Angelman syndrome: a parallel mouse and human analysis
MS Sidorov, GM Deck, M Dolatshahi, RL Thibert… - Journal of …, 2017 - Springer
Journal of neurodevelopmental disorders, 2017•Springer
Background Clinicians have qualitatively described rhythmic delta activity as a prominent
EEG abnormality in individuals with Angelman syndrome, but this phenotype has yet to be
rigorously quantified in the clinical population or validated in a preclinical model. Here, we
sought to quantitatively measure delta rhythmicity and evaluate its fidelity as a biomarker.
Methods We quantified delta oscillations in mouse and human using parallel spectral
analysis methods and measured regional, state-specific, and developmental changes in …
EEG abnormality in individuals with Angelman syndrome, but this phenotype has yet to be
rigorously quantified in the clinical population or validated in a preclinical model. Here, we
sought to quantitatively measure delta rhythmicity and evaluate its fidelity as a biomarker.
Methods We quantified delta oscillations in mouse and human using parallel spectral
analysis methods and measured regional, state-specific, and developmental changes in …
Background
Clinicians have qualitatively described rhythmic delta activity as a prominent EEG abnormality in individuals with Angelman syndrome, but this phenotype has yet to be rigorously quantified in the clinical population or validated in a preclinical model. Here, we sought to quantitatively measure delta rhythmicity and evaluate its fidelity as a biomarker.
Methods
We quantified delta oscillations in mouse and human using parallel spectral analysis methods and measured regional, state-specific, and developmental changes in delta rhythms in a patient population.
Results
Delta power was broadly increased and more dynamic in both the Angelman syndrome mouse model, relative to wild-type littermates, and in children with Angelman syndrome, relative to age-matched neurotypical controls. Enhanced delta oscillations in children with Angelman syndrome were present during wakefulness and sleep, were generalized across the neocortex, and were more pronounced at earlier ages.
Conclusions
Delta rhythmicity phenotypes can serve as reliable biomarkers for Angelman syndrome in both preclinical and clinical settings.
Springer