The cytokine network in acute myeloid leukemia (AML): A focus on pro-and anti-inflammatory mediators
S Binder, M Luciano, J Horejs-Hoeck - Cytokine & growth factor reviews, 2018 - Elsevier
Cytokines exert profound effects on the progression of hematopoietic malignancies such as
acute myeloid leukemia (AML). Critical roles of cytokines in the context of inflammation have
gained special interest. While pro-inflammatory mediators such as IL-1β, TNF-α and IL-6
tend to increase AML aggressiveness, anti-inflammatory mediators such as TGF-β and IL-10
appear to impede AML progression. Dysregulation of the complex interactions between pro-
and anti-inflammatory cytokines in AML may create a pro-tumorigenic microenvironment …
acute myeloid leukemia (AML). Critical roles of cytokines in the context of inflammation have
gained special interest. While pro-inflammatory mediators such as IL-1β, TNF-α and IL-6
tend to increase AML aggressiveness, anti-inflammatory mediators such as TGF-β and IL-10
appear to impede AML progression. Dysregulation of the complex interactions between pro-
and anti-inflammatory cytokines in AML may create a pro-tumorigenic microenvironment …