Role of SHP2 in hematopoiesis and leukemogenesis
R Pandey, M Saxena, R Kapur - Current opinion in hematology, 2017 - journals.lww.com
R Pandey, M Saxena, R Kapur
Current opinion in hematology, 2017•journals.lww.comSHP2 has emerged as an attractive target for therapeutic targeting in hematological
malignancies for its cell autonomous and microenvironmental effects. However a better
understanding of the role of SHP2 in different hematopoietic lineages and its crosstalk with
signaling pathways activated by other genetic lesions is required before the promise is
realized in the clinic.
malignancies for its cell autonomous and microenvironmental effects. However a better
understanding of the role of SHP2 in different hematopoietic lineages and its crosstalk with
signaling pathways activated by other genetic lesions is required before the promise is
realized in the clinic.
Summary
SHP2 has emerged as an attractive target for therapeutic targeting in hematological malignancies for its cell autonomous and microenvironmental effects. However a better understanding of the role of SHP2 in different hematopoietic lineages and its crosstalk with signaling pathways activated by other genetic lesions is required before the promise is realized in the clinic.
Lippincott Williams & Wilkins