[HTML][HTML] Evidence that retinoic acid receptor β induction by retinoids is important for tumor cell growth inhibition
SY Sun, H Wan, P Yue, WK Hong, R Lotan - Journal of Biological Chemistry, 2000 - ASBMB
Retinoic acid receptor β (RARβ) is thought to be involved in suppressing cell growth and
tumorigenicity. Many premalignant and malignant cells exhibit a reduced RARβ expression.
However, in some of these cells (eg H157 human squamous cell carcinoma cells), RARβ
can be induced by retinoids (eg all-trans-retinoic acid, ATRA) because its promoter contains
a retinoic acid response element. To examine the hypothesis that RARβ induction is
important for inhibition of cell proliferation by retinoids, we blocked ATRA-induced RARβ …
tumorigenicity. Many premalignant and malignant cells exhibit a reduced RARβ expression.
However, in some of these cells (eg H157 human squamous cell carcinoma cells), RARβ
can be induced by retinoids (eg all-trans-retinoic acid, ATRA) because its promoter contains
a retinoic acid response element. To examine the hypothesis that RARβ induction is
important for inhibition of cell proliferation by retinoids, we blocked ATRA-induced RARβ …