Manganese in human parenteral nutrition: considerations for toxicity and biomonitoring
D Santos, C Batoreu, L Mateus, APM Dos Santos… - Neurotoxicology, 2014 - Elsevier
The iatrogenic risks associated with excessive Mn administration in parenteral nutrition (PN)
patients are well documented. Hypermanganesemia and neurotoxicity are associated with
the duration of Mn supplementation, Mn dosage, as well as pathological conditions, such as
anemia or cholestasis. Recent PN guidelines recommend the biomonitoring of patients if
they receive Mn in their PN longer than 30 days. The data in the literature are conflicting
about the method for assessing Mn stores in humans as a definitive biomarker of Mn …
patients are well documented. Hypermanganesemia and neurotoxicity are associated with
the duration of Mn supplementation, Mn dosage, as well as pathological conditions, such as
anemia or cholestasis. Recent PN guidelines recommend the biomonitoring of patients if
they receive Mn in their PN longer than 30 days. The data in the literature are conflicting
about the method for assessing Mn stores in humans as a definitive biomarker of Mn …