[HTML][HTML] The orphan nuclear receptor NR4A1 protects pancreatic β-cells from endoplasmic reticulum (ER) stress-mediated apoptosis
C Yu, S Cui, C Zong, W Gao, T Xu, P Gao… - Journal of Biological …, 2015 - ASBMB
The role of NR4A1 in apoptosis is controversial. Pancreatic β-cells often face endoplasmic
reticulum (ER) stress under adverse conditions such as high free fatty acid (FFA)
concentrations and sustained hyperglycemia. Severe ER stress results in β-cell apoptosis.
The aim of this study was to analyze the role of NR4A1 in ER stress-mediated β-cell
apoptosis and to characterize the related mechanisms. We confirmed that upon treatment
with the ER stress inducers thapsigargin (TG) or palmitic acid (PA), the mRNA and protein …
reticulum (ER) stress under adverse conditions such as high free fatty acid (FFA)
concentrations and sustained hyperglycemia. Severe ER stress results in β-cell apoptosis.
The aim of this study was to analyze the role of NR4A1 in ER stress-mediated β-cell
apoptosis and to characterize the related mechanisms. We confirmed that upon treatment
with the ER stress inducers thapsigargin (TG) or palmitic acid (PA), the mRNA and protein …