[HTML][HTML] Temporal characterization of β cell-adaptive and-maladaptive mechanisms during chronic high-fat feeding in C57BL/6NTac mice
D Gupta, TL Jetton, K LaRock, N Monga… - Journal of Biological …, 2017 - ASBMB
The onset of type 2 diabetes is characterized by transition from successful to failed insulin
secretory compensation to obesity-related insulin resistance and dysmetabolism. Energy-
rich diets in rodents are commonly studied models of compensatory increases in both insulin
secretion and β cell mass. However, the mechanisms of these adaptive responses are
incompletely understood, and it is also unclear why these responses eventually fail. We
measured the temporal trends of glucose homeostasis, insulin secretion, β cell …
secretory compensation to obesity-related insulin resistance and dysmetabolism. Energy-
rich diets in rodents are commonly studied models of compensatory increases in both insulin
secretion and β cell mass. However, the mechanisms of these adaptive responses are
incompletely understood, and it is also unclear why these responses eventually fail. We
measured the temporal trends of glucose homeostasis, insulin secretion, β cell …