Disruption of renal tubular mitochondrial quality control by Myo-inositol oxygenase in diabetic kidney disease
M Zhan, IM Usman, L Sun… - Journal of the American …, 2015 - journals.lww.com
Diabetic kidney disease (DKD) is associated with oxidative stress and mitochondrial injury.
Myo-inositol oxygenase (MIOX), a tubular-specific enzyme, modulates redox imbalance and
apoptosis in tubular cells in diabetes, but these mechanisms remain unclear. We
investigated the role of MIOX in perturbation of mitochondrial quality control, including
mitochondrial dynamics and autophagy/mitophagy, under high-glucose (HG) ambience or a
diabetic state. HK-2 or LLC-PK1 cells subjected to HG exhibited an upregulation of MIOX …
Myo-inositol oxygenase (MIOX), a tubular-specific enzyme, modulates redox imbalance and
apoptosis in tubular cells in diabetes, but these mechanisms remain unclear. We
investigated the role of MIOX in perturbation of mitochondrial quality control, including
mitochondrial dynamics and autophagy/mitophagy, under high-glucose (HG) ambience or a
diabetic state. HK-2 or LLC-PK1 cells subjected to HG exhibited an upregulation of MIOX …